Researchers have now discovered a gut-brain connection in patients who suffer from autism.
Chief Investigator Associate Professor Elisa Hill-Yardin from RMIT University said scientists trying to understand autism have long studied the brain, but the links with the gut nervous system have only been recently explored.
BYPASS THE CENSORS
Sign up to get unfiltered news delivered straight to your inbox.
Eurekalert.org reports: “We know the brain and gut share many of the same neurons and now for the first time we’ve confirmed that they also share autism-related gene mutations,” Hill-Yardin said.
REVEALED: Biden’s IRS In Training To Carry Out Armed Raids on Suburban Homes
Anne Heche Was About To Expose Hollywood Pedophile Ring Before She Died
Operation Mockingbird: MSM Caught Reading EXACT Same Script About FBI’s Trump Raid
How Rockefeller Founded Big Pharma And Waged War On Natural Cures
Bombshell Evidence PROVES Justin Trudeau Is Fidel Castro’s Son
The Global Elites Are Normalizing Pedophilia
Uri Geller Threatens To Nuke Russia Using Just His Psychic Powers
UN Declares Conspiracy Theorists "Public Enemy no.1"
Tesla’s Greatest Inventions Promised ‘Bright Future’ For Humanity Until the Elite Destroyed Them
“Up to 90% of people with autism suffer from gut issues, which can have a significant impact on daily life for them and their families.
“Our findings suggest these gastrointestinal problems may stem from the same mutations in genes that are responsible for brain and behavioural issues in autism.
“It’s a whole new way of thinking about it – for clinicians, families and researchers – and it broadens our horizons in the search for treatments to improve the quality of life for people with autism.”
The autism gene and the gut-brain link
The study reveals a gene mutation that affects neuron communication in the brain, and was the first identified as a cause of autism, also causes dysfunction in the gut.
The research brings together new results from pre-clinical animal studies with previously unpublished clinical work from a landmark 2003 study led by Swedish researchers and a French geneticist.
The study of two brothers with autism by Professor Christopher Gillberg (University of Gothenburg), Professor Maria Råstam (Lund University) and Professor Thomas Bourgeron (Pasteur Institute) was the first to identify a specific gene mutation as a cause of the neurodevelopmental disorder.
This mutation affects communication by altering the “velcro” between neurons that keeps them in close contact.
While the 2003 study was focused on identifying the genetic basis for autism, Gillberg and Råstam also took detailed clinical notes of the brothers’ significant gastrointestinal problems.
Researchers in the Gut-Brain Axis team at RMIT have built on this clinical work with a series of studies on the function and structure of the gut in mice that have the same “velcro” gene mutation.
They team found this mutation affects:
- gut contractions
- the number of neurons in the small intestine
- the speed that food moves through the small intestine
- responses to a critical neurotransmitter important in autism (well known in the brain but not previously identified to play any major role in the gut)
Collaborator Associate Professor Ashley Franks (La Trobe University) also found significant differences in the gut microbes of mice with the mutation and those without it, even though both groups were kept in identical environments.
While this specific “velcro” mutation is rare, it is one of more than 150 autism-related gene mutations that alter neuronal connections, Hill-Yardin said.
“The link we’ve confirmed suggests a broader mechanism, indicating that the mutations that affect connections between neurons could be behind the gut problems in many patients.”
New research horizons on the gut-brain axis
Hill-Yardin, an ARC Future Fellow and Vice-Chancellor’s Senior Research Fellow in the School of Health and Biomedical Sciences at RMIT, said the work identifies a new a target for the development of therapies specifically designed to work on neurotransmitters in the gut.
“We’ve also identified that there’s a need to better understand how existing autism medications that target neurotransmitters in the brain are affecting the gut,” she said.
“Another promising path for future research is investigating how gene mutations in the nervous system relate with microbes in the gut.
“We know these microbes interact with the brain via the gut-brain axis, so could tweaking them improve mood and behaviour?
“While this wouldn’t reverse the gene mutation, we might be able to tone down its effects, and make a real difference in the quality of life for people with autism and their families.”
Latest posts by Sean Adl-Tabatabai (see all)
- Massive Pedophile Ring Busted, Dozens of Children Rescued across US - August 18, 2022
- Fully Jabbed New Zealanders SEVEN TIMES Sicker This Year than Pre-COVID - August 18, 2022
- A Massive ‘Cannibal Coronal Mass Ejection’ Is About to Strike Earth - August 18, 2022